Which nasal sprays have epinephrine

Based on the amount of time it took the medication to reach maximum concentration, the epinephrine nasal spray absorption rate was faster than intramuscular injections 20 minutes versus 45 minutes. The epinephrine nasal spray had a higher peak of epinephrine concentration compared to the 0. Overall, the epinephrine nasal spray delivered a more consistent exposure and hemodynamic response within the first 20 minutes.

Epinephrine nasal spray was again found to have bioequivalent exposure with comparable peak concentrations compared to intramuscular dosing by 0. The epinephrine nasal spray absorption rate was also faster than EpiPen injections. These studies also took note of any adverse events that occurred due to the nasal administration of epinephrine. Overall it was well-tolerated with mostly mild adverse events and no significant nasal pain or irritation.

Lockey added. The researchers assisted in the simulated use of both the nasal epinephrine and epinephrine auto-injectors. Patients were also more likely to recommend this product to others. Beckman said that the nasal epinephrine device is still in development and that no application has been filed yet with the FDA. Soosaar J, et al. Multicenter, randomized crossover preference study of Bidose epinephrine nasal spray vs. Read next. November 05, You're a nasal-spray junkie, and you're not alone.

We ask what they've tried, and they'll say, 'Nasal spray, three to four times a day -- for a year -- or two. Adrenaline naturally shrinks our blood vessels, which explains why when you run or exercise, your nose opens up because there's adrenaline going through your system. You get more congested at night because your adrenaline shuts off when you sleep.

Add a cold or allery and the turbinates swell even more, Bussell said. When you try to stop using the spray, your own body's adrenaline isn't strong enough to take over. It takes about a week of being off the product for your body to recalibrate and start responding to your own body's adrenaline again.

It wakes me every morning, and I won't sleep if I forget to use the nasal spray before bedtime.