Why do ssri cause sweating

Adding a medication to reduce diaphoresis may be appropriate. Sympathetic division of the peripheral nervous system signals cholinergic neurons to stimulate sweat gland secretion. In the CNS, thermoregulation occurs in the hypothalamus through a balanced and complex interaction among serotonergic and dopaminergic neurons.

Although evidence is limited to case reports, consider cholinergic and serotonergic antagonists and dopamine partial agonists to relieve antidepressant-induced diaphoresis.

Peripherally, the anticholinergic agent benztropine reduced or eliminated diaphoresis at doses ranging from 0. Centrally acting serotonin antagonists may decrease diaphoresis through the 5-HT2A receptor, which signals the hypothalamus to raise body temperature. Cyproheptadine is an antihistamine with serotonin receptor antagonism. As a rule, begin with an antidepressant that has shown better tolerance at the lowest dose, then titrate slowly.

Careful monitoring should focus on tolerance as well as on symptom alleviation. It is important to distinguish adverse effects from depression symptoms, such as fatigue and carbohydrate craving. Should bothersome adverse effects emerge, watchful waiting is often a reasonable option, since most adverse effects diminish over time.

Either reducing the dose or adjusting the dosing schedule can be tried before switching to another antidepressant. If this strategy is not successful, the off-label addition of other pharmacological agents can be considered. Psychol Med. Compliance with antidepressants in a primary care setting, 1: beyond lack of efficacy and adverse events. J Clin Psychiatry. Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report versus physician estimate.

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Testosterone improves antidepressant-emergent loss of libido in women: findings from a randomized, double-blind, placebo-controlled trial. J Sex Med. Bahrick AS. Persistence of sexual dysfunction side effects after discontinuation of antidepressant medications: emerging evidence. Open Psychol J.

Demyttenaere K, Jaspers L. Review: bupropion and SSRI-induced side effects. J Psychopharmacol. Jonathan Scarff lays out options for treating antidepressant induced sweating. At the time of this writing, Dr. By the way, you can find a comprehensive list of medications that can cause sweating as a side-effect on our website by clicking here. Twenty-two percent of these people, reports Dr. Scarff, experience excessive sweating as a side-effect of their medication.

This type of sweating is called secondary hyperhidrosis as opposed to primary hyperhidrosis , which is a medical condition unto itself. The unpleasant sweating that is secondary to antidepressants may be severe enough for patients to discontinue their treatment with obvious negative impacts. Preserving the benefits of antidepressant treatment while counteracting untoward sweating is, therefore, an important goal. A goal that Dr. Scarff suggests can be reached through the use of oral agents.

Scarff has found that the anticholinergic benztropine reduced or eliminated antidepressant-related sweating with doses ranging from 0. Dry mouth was the only reported side-effect.