Why does ace inhibitors increase urine production

After a heart attack, some of the heart muscles weaken and become damaged. These heart muscles may continue to weaken as time goes by. This makes it more difficult for the heart to pump blood.

Ramipril may be started within the first few days after a heart attack to increase the survival rate. Ramipril is also used to lessen the chance of having heart attacks or strokes in patients 55 years of age or older with serious heart disease.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of ramipril in the pediatric population.

Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ramipril in the elderly.

However, elderly patients are more likely to have age-related heart, kidney, or liver problems, which may require an adjustment in the dose for patients receiving ramipril.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.

In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.

If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.

Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium salt. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Remember that this medicine will not cure your high blood pressure but it does help control it.

Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. Your reply, once signed off, will appear below the comment to which you replied if multiple replies to a comment, they will appear in order of submission. You can still add a fresh comment by scrolling to the bottom of the discussion and clicking the "Add a comment" button. If someone adds a reply to one of your comments or replies you will recieve an email notifying you of this.

You can opt out of or into if currently out all comment notification emails by clicking the button below. Made with by the bpac nz team. Prescribing Reports. CME Quizzes. Peer Group Discussions. My Bpac account. Search Mybpac - Login. Latest Articles View Articles. Prescribing Reports View reports. Audits View all audits. Peer Group Discussions View all discussions. Hello there! Remember me. This item is 3 years and 6 months old; some content may no longer be current. Adverse drug reactions and interactions Medicines management Neurology Pain management.

Please login to save this article. Log in. Identifying patients at risk of the triple whammy Risk factors for triple whammy-induced AKI are similar to other forms of kidney injury and include: 3—5 Any stage of chronic kidney disease CKD Older age, e.

Advice for patients who are taking all three medicines Maintain a good fluid intake to avoid volume depletion, particularly if feeling unwell or in hot weather see below for advice if the patient is acutely unwell. Managing triple whammy adverse effects if they do occur The term AKI covers a spectrum from relatively small decreases in urine output and retention of waste products to complete kidney failure.

When to seek further advice for patients with AKI Patients with AKI that is secondary to medicine use alone and who respond rapidly to treatment, i. Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study.

BMJ ;e NSAIDs and acute kidney injury. Kidney Int ;— The triple whammy - safe prescribing - a dangerous trio. Available from: www. Int J Equity Health ; Nefrologia ;— A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.

After removal of similar amounts of plasma water by extracorporeal ultrafiltration, body weight decreased in both groups but the decrease was maintained in the following days only in Group II patients. A transient reduction 48 hours of both plasma volume and urinary output was observed after ultrafiltration in both groups.

Despite plasma renin activity and aldosterone increase, urinary electrolytes response to ultrafiltration was different in the two groups: sodium and chloride were reduced, and potassium did not change in Group 1 while, in Group II, sodium and chloride did not change and potassium excretion was significantly increased.

In conclusion, chronic treatment with ACE-inhibitors does not enhance the excretion of sodium in congestive heart failure but just mitigates potassium loss.